1.
Am J Respir Cell Mol Biol
; 68(5): 594-597, 2023 05.
Article
in English
| MEDLINE | ID: covidwho-2312849
Subject(s)
COVID-19 , Humans , Whole Genome Sequencing , DNA Methylation , Epigenesis, Genetic , Hospitals
2.
Clin Epigenetics
; 14(1): 94, 2022 07 23.
Article
in English
| MEDLINE | ID: covidwho-1957069
ABSTRACT
We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year after discharge. Of the 1505 acute illness-induced differentially methylated regions (DMRs) previously identified, we found 71 regions with persisted differentially methylated, with an average of 7 serial CpG positions per DMR. Sixty-four DMRs persisted hypermethylated, and 7 DMR persisted hypomethylated. These data are the first reported evidence that DNA methylation changes in circulating leukocytes endure long after recovery from acute illness.